Impairment of APE1 Function Enhances Cellular Sensitivity to Clinically Relevant Alkylators and Antimetabolites
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چکیده
منابع مشابه
Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites.
Base excision repair (BER) is the major pathway for removing mutagenic and cytotoxic oxidative and alkylation DNA modifications. Using a catalytically inactive, dominant negative protein form of human APE1, termed ED, which binds with high affinity to substrate DNA and blocks subsequent repair steps, we assessed the role of BER in mediating cellular resistance to clinically relevant alkylating ...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2009
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-08-0519